Molecular architectures refer to the three-dimensional structures and physical organization of molecules. Such architectures can be used to create complex biological organisms as well as a range of materials and products. At its most basic level, molecular architecture is constructed from the arrangement of atoms within a molecule. These arrangements are formed through the establishment of covalent bonds, the sharing of electrons between two different chemical elements. Depending on the covalent bond type, varying numbers of electrons can be shared between the two atoms. The number of electrons shared dictates whether those atoms experience an attraction, repulsion, or a combination of both. It is this interplay between covalent bonds, and thus the arrangement of atoms, that is integral to the understanding of molecular architecture. The architecture for a particular molecule will also depend on the types of chemical bonds that act to connect the atoms or groups of atoms. These five major types are; ionic, covalent, metallic, hydrogen, and van der Waals. Depending on the type of bond and the corresponding intermolecular interactions, the molecular structure of the compounds can vary significantly. Beyond the arrangement of atoms, the specific structure of a molecular is also dictated by its shape. This shape is known as the conformation. This conformation is determined by the number of atoms within a molecule and the forces between them, including electrostatic and dipolar forces. A more complex conformation translates to a greater number of potential interactions with other molecules, which can in turn alter chemical properties. In conclusion, molecular architecture provides an understanding into how atoms arrange themselves into molecules. It is essential in the formation of complex biological organisms, materials, and products. The architecture of a molecule is determined by the arrangement of its covalent bonds, the number of atoms, and the specific type of bonding. The shape of these molecules, the conformation, is also determined by the same factors and describes the varying potential interactions.