Drug delivery and therapeutics represent a pivotal frontier in the realm of healthcare, revolutionizing the way medications are administered and optimizing treatment outcomes. At its core, drug delivery encompasses the science and technology behind delivering therapeutic agents to their intended sites of action within the body, while therapeutics focuses on the application of these agents to treat diseases and improve patient health. With advancements in pharmaceutical research and engineering, a plethora of innovative drug delivery systems have emerged, each tailored to address specific challenges associated with conventional drug administration routes.
From oral tablets and injections to transdermal patches and inhalers, drug delivery systems vary widely in their mechanisms of action, offering diverse options for clinicians and patients alike. Oral drug delivery remains one of the most prevalent methods due to its convenience and patient compliance, wherein medications are ingested and absorbed through the gastrointestinal tract. However, challenges such as low bioavailability and variability in absorption rates have prompted the development of novel formulations, including controlled-release tablets and nanoparticles, which enhance drug stability and ensure sustained release profiles.
Intravenous and intramuscular injections provide rapid and direct access to the bloodstream, bypassing the gastrointestinal barrier and offering precise control over drug dosage. These routes are particularly advantageous for critical care scenarios and emergency treatments, where immediate drug action is imperative. Furthermore, advancements in nanotechnology have facilitated the design of targeted drug delivery systems, wherein nanoparticles are engineered to selectively accumulate in diseased tissues, minimizing systemic side effects and maximizing therapeutic efficacy.
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Thomas J Webster, Brown University, United States
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Hossam A Gabbar, Ontario Tech University, Canada
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Azeez A Barzinjy, Soran University, Iraq