Title : Comparative study of erysimum cheiranthoides extracts obtained with different solvents for potential application in advanced wound healing biomaterials
Abstract:
The increasing number of chronic and hard-to-heal wounds has created a growing demand for new therapeutic approaches that accelerate tissue repair while reducing the risk of infection and complications. This study aimed to compare the properties of plant extracts obtained from Erysimum cheiranthoides using different solvents and to evaluate their potential as bioactive additives in advanced wound dressing biomaterials.
Extracts prepared under various extraction conditions were characterized for their in vitro anti-inflammatory and antioxidant activities and subsequently incorporated into biomaterials composed of inulin, mannan, and sodium alginate. The resulting systems were crosslinked with dialdehyde inulin, a biocompatible and biodegradable crosslinker that represents a safer alternative to glutaraldehyde. The biomaterials were additionally supplemented with vitamin B12, known to stimulate cell proliferation.
The applied biopolymers provide adequate wound hydration and support healing processes with a low risk of allergic reactions. Extracts from Erysimum cheiranthoides demonstrated high anti-inflammatory activity (up to 90.88%) and antioxidant capacity (up to 92.48%), with solvent-dependent differences observed.
The resulting biomaterials exhibited promising preliminary biocompatibility and bioactivity, indicating the potential of plant extracts obtained via various extraction methods as components of advanced wound-healing dressings.
