Title : Green chemistry and its implementation in pharmaceutical analysis
Abstract:
The expanding progression of industrial development has been a pioneer for world economic growth. Green chemistry has been defined as ‘the employment of techniques and methodologies that reduce or eliminate the use or production of feedstocks, products, by-products, solvents, and reagents that are harmful to human health or the environment’. The quality-by-design approach is well-known in the pharmaceutical industry, and it has a great influence on analytical methods and procedures. In the green method of chemistry, the core consideration is directed towards the design of a material or the chemical procedure; four of twelve principles are associated with design, e.g. designing fewer hazardous chemical syntheses, designing harmless chemicals and products, designing for energy effectiveness, and designing for degradation. Green chemistry’, ‘clean chemistry’, and ‘benign chemistry’ are all terms used to describe approaches that minimize the use of feedstocks and consumption of reagents and energy, as well as the generation of wastes in the analytical and chemical industry, to protect the environment and save the materials. Thus, there is a high awareness on greening the available analytical methods by which several alternatives and schemes have been proposed. This is based on reducing the amount of reagents, solvent depletion, waste minimization and recycling, and passivation and degradation of toxic wastes. One of the most active fields of research and development in green chemistry is the establishment of analytical methodologies, leading to the beginning of so-called green analytical chemistry. The influences of green chemistry on pharmaceutical analysis, the environment, the population, the analyst, and companies are discussed in this review, and they are multidimensional. Every selection and analytical attitude affects both the end-product and everything that surrounds it.
