Abstract:
Ionophores are compounds that facilitate the transport of ions across cellular membranes, disrupting the normal ionic balance within cells. This disruption can lead to various cellular responses, including apoptosis (programmed cell death), making ionophores potential candidates in cancer therapy. Ion homeostasis is crucial for the survival of both normal and neoplastic cells. Disruptions in ion balance are characteristic of cancer cells, prompting the exploration of ionophores agents that modulate ion transport as potential anticancer treatments. Notable ionophores such as Valinomycin, Nigericin, and Obatoclax have demonstrated significant anticancer activities, particularly against cancer stem-like cells, which are often resistant to conventional therapies and contribute to tumor recurrence.
Keywords: Ionophores, homeostasis, neoplastic cells and anticancer activities etc.
Biography:
Dr. Asish Bhaumik is an Associate Professor in the Department of Pharmaceutical Chemistry at the School of Pharmaceutical Sciences (SOPS), Girijananda Chowdhury University (GCU), Tezpur, Assam, where he joined on March 15, 2023. He teaches courses such as Medicinal Chemistry, Pharmaceutical Organic Chemistry, Therapeutic Chemistry, Biochemistry, and Pharmaceutical Analysis. Dr. Bhaumik earned his Ph.D. in Pharmaceutical Science with a focus on Medicinal Chemistry from Assam Downtown University in 2022. He also holds an M. Pharm in Pharmaceutical Chemistry from The Tamil Nadu Dr. MGR Medical University (2012) and a B. Pharm from RIPSAT (2003). Additionally, he has graduate diplomas in Clinical Research and Applied and Industrial Biotechnology. Dr. Bhaumik has contributed significantly to pharmaceutical sciences through his authorship and patent holdings. He has authored textbooks such as "A Textbook of Pharmacology II (BP503T)" and "A Textbook of Pharmaceutical Biotechnology (BP605T)". He also holds two UK design patents and seven Indian patents, reflecting his innovative research in the field. In addition to his academic and research pursuits, Dr. Bhaumik has actively participated in national and international conferences, presenting papers and engaging with the broader scientific community. His dedication to continuous learning is evident through his attendance at various faculty development programs, quality improvement programs (18), short-term courses, and workshops (7) organized by reputed universities and institutions. Dr. Asish Bhaumik is currently supervising four Ph.D. scholars in the Department of Pharmaceutical Chemistry at the School of Pharmaceutical Sciences, Girijananda Chowdhury University (GCU), Tezpur.
