Title : Contribution to the valorization of tetraclinis articulata (thuya) wood sawdust: hemisynthesis and anticancer activity of natural and hemisynthetic products
Abstract:
Objectives
The initial phase of this study involves isolating and characterizing the primary constituents of biomass derived from the plant. The subsequent phase focuses on the chemical modification of these isolated natural components to synthesize new pentagonal heterocyclic compounds, including thiazolidinones, thiadiazoles, thiazolines, isoxazoles, and 1,2,3-triazoles, which are recognized for their anticancer activities.
Methods
To achieve our objectives, we will employ a comprehensive approach. First, we will extract the chemical compounds present in the sawdust of the plant wood. Next, we will conduct hemisynthesis reactions to produce new compounds. These compounds will be characterized using advanced analytical techniques, such as NMR spectroscopy and chromatography. Finally, we will evaluate their anticancer activity.
Results
The outcomes of this research could have significant implications. Primarily, we aim to add value to an often-overlooked industrial byproduct by proposing a sustainable and environmentally friendly application, thereby contributing to climate change mitigation. Furthermore, the identification of new natural or hemisynthetic products with anticancer activity could pave the way for the development of more effective and less toxic anticancer drugs.
Keywords: Abietane diterpenes ? 1,2,3-Triazole ?Thiazolidinone ? Hybrid compounds ? ? Molecular docking ? Cytotoxic activity
