Study of several antimicrobials, physical proprieties

Title : Study of several antimicrobials, physical proprieties

Abstract:

Theoretical and experimental study were conducted on several antimicrobials (ex: p-tolyl 2-Acetamido-3-(4-Fluorophenyl)Propanoate (AFP), novel bioactive molecule 2-(3-Bromobenzoyl)-n-Methylhydrazine-1-Carboxamide (BMC), (E)-4-methoxy-N′-(2-(Trifluoromethyl)benzylidene) benzohydrazide (EMT) etc etc). Density Functional Theory (DFT), Time Dependent (TD)-DFT and Surface Enhanced Raman Scattering (SERS) studies are reported for the adsorption on silver hydrosols. SERS at various concentrations are discussed and their orientation changes with concentration are studied. After adsorption on silver surface, the structural properties of antimicrobials exhibit somtetimes modifications, indicating an interaction between them and Ag6 cluster. On some samples molecular docking are performed to find their ability to bind to target proteins. Silver nanoparticles are successfully used for the treatment of different diseases alone or in association with other active components and the incorporation of antimicrobials with silver nanocolloids could act as a nanodrug delivery system. The findings presented could futhermore help in the construction of more dependable SERS sensors by thoroughly describing the concentration-dependent profile of analyte orientation.

Keywords: Antimicrobials, SERS Raman, DFT, Docking.

Audience Take Away Notes

• Identification and characterizations of antimicrobials
• Application of Raman spectroscopy in antimicrobials analysis
• Notions on SERS colloids

Biography:

Maria Cristina Gamberini has a degree in Chemistry, her first period abroad at the Polytechnic of Lausanne has been dedicated to the study of nanomaterials using spectroscopic techniques, studies of pigments and minerals. She is professor at the University of Modena and Reggio Emilia in the Chemistry Laboratory. Her main scientific interest is linked to the experimentation of the Raman Spectroscopy Technique on simple or complex matrices. For years she has studied crystals and cocrystals and polymorphs. The study and characterization of inorganic samples in collaboration with various international groups has allowed the publication of numerous articles in international journals. She has been a speaker at several international conferences. The study is currently focused on Raman spectral identification and characterization of inorganic and also organic samples.