Title : Synthesis and structural analysis of 13-93B3 bioactive borate glass with low copper dopant for bio-applications
Abstract:
13-93B3 bioactive borate glasses were successfully synthesized via conventional melt quenching method with nominal composition of (6Na2O.12K2O. 5MgO. 20CaO. 4P2O5. (53-x) B2O3. xCuO Wt%) (0≤ x ≤ 0.6 wt%). X-ray diffraction measurements revealed that the produced samples were amorphous without any tendency for crystallization. Using the deconvolution analysis technique (DAT) coupled with Fourier transform Infrared (FT-IR) spectral measurement to investigate the structural changes inside the glassy matrix, which were examined to estimate the percent of tetrahedral boron change against doping copper ion concentration. The study revealed that copper additions regulate the transformation of triangular and tetrahedral coordinated boron, leading to an increase in copper content up to 0.4 wt%. The UV/vis spectroscopic technique showed the absorption band in visible region and was also used to calculate the optical energy gap. Antimicrobial activity against various pathogenic grams was tested using a cup and disc diffusion method; all tested samples showed a clear inhibition zones, which correlated to the copper oxide doping level. The cytotoxicity assay was estimated for some selected samples and proved a good cell viability and no present of toxic effect. All obtained results confirmed the use of the formed glass in biomedical applications, e.g., wound healing.
