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5th Edition of

Chemistry World Conference

June 02-04, 2025 | Rome, Italy

Chemistry 2024

Promize of herbal drugs in improving cancer radiotherapy

Speaker at Chemistry World Conference 2024 - Kaushala Prasad Mishra
Bhabha Atomic Research Center, India
Title : Promize of herbal drugs in improving cancer radiotherapy

Abstract:

Cancer incidence and mortality have been rapidly increasing in the industrialized world. Discovery of new drugs for cancer treatment has been a challenging task for pharmaceutical companies. Frequently observed problems of general toxicity, exorbitant cost and non-specific action pose profound limitations in treatment of cancer patients. Among the treatment modalities, chemotherapy and radiotherapy account for more than 75 % of patient treatment. A predicament is faced in clinic because drug as well as radiation kill equally both cancer and normal cells of the patients producing undesirable side effects compelling sometimes abandoning of the treatment. Research is, therefore, needed to develop non-toxic and affordable drugs for effective treatment of patients. To meet these objectives, our laboratory has actively been investigating to develop novel drugs from plant kingdom and targeted approaches for selectively killing the cancer cells but sparing the normal cells. Apart from surgery and chemotherapy, the modality of radiotherapy is a often employed mode of cancer patient treatment. While considerable improvement has been made in delivering the radiation to target diseased tissue but technical limitations yet pose many daunting challenges. A developing strategy that holds promise in treatment of cancer patients consists in searching for natural compounds with toxic properties which can selectively enhance tumor cell toxicity to radiation but spare normal cells as desired in clinical settings.  Recent research from screening studies have found some potent phytodrugs from plant kingdom which display unique ability to cause no or minimal toxicity to normal cells but remarkably sensitize tumor cells to ionizing radiation. The mechanism involves the radiation generated reactive oxygen species (ROS) which trigger induction of apoptosis (cellular suicide) in tumor cells because of the high oxidative stress status in these cells.  This talk is designed to present a brief highlight of developing plant based herbal drugs for improving chemo and radiotherapy of cancer patients. Major part of the talk is based on the recent research results from our laboratory.  A few examples of notable herbals such as Triphala, Ellagic acid and Silibinin will be given for the observed increased tumor cytotoxicity in tumor cells by certain compounds from plant sources which hold promise of improving treatment of cancer patients in radiotherapy.

Biography:

Prof Dr K.P. Mishra post graduated in Chemistry from University of Allahabad. He joined prestigious National Institute, Bhabha Atomic Research Center, Mumbai as Research Scientist in nuclear Science and Technology. He grew upwards from position to position and served  in the research field for more than 4 decades. He specialized in chemo-biolocal sciences, Free Radical Biology, Radiation and Cancer Biology, Biotechnology and Life Sciences.  He rose to the level of Senior Professor and remained HOD for many years.  He is serving on Editorial Boards of about a dozen reputed Journals. He has published more than 350 research papers in refereed reputed journals. He guided and mentored 51 Ph.D. students.

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