Title : Donor-acceptor interaction between biologically active hesperetin 7-rhamnoglucoside and ?-acceptors DDQ and TCNE
Abstract:
The interactions between a biologically active flavonoid, Hesperetin 7-rhamnoglucoside ( HESP) and two of the most known π- acceptors DDQ and TCNE were investigated leading to two new charge transfer complexes (CTC). UV- Visible spectrophotometry was used to follow the reactions in solution in methanol and ethanol as sol- vents. Infrared and NMR spectrophotometry was used to characterize the products formed in the solid state reactions. The1:1 stoichiometry of formed charge transfer complexes (HESP-DDQ and HESP-TCNE) was con- firmed by Molar ratio method and Benesi-Hildbrand equation was used to calculate the formation constants K CT and the molar extinction coefficient ? CT of the formed CTC. CTC formed in the reaction of Hesperetin 7-rhamnoglucoside with π-acceptors DDQ and TCNE showed high formation constants K CT. K CT values for both CTC formed in ethanol are higher than those formed in methanol and those found for the HESP-DDQ CTC were higher than those of HESP-TCNE. Our results suggest the formation of stable CT complexes of Hesperetin 7-O-rhamnoglucoside with π-acceptors DDQ and TCNE which could enhance biological properties of this phytochemical and accelerates its use a full-fledged medicine.
Audience Take Away:
- Improvement of bioavailability of plant metabolites through charge transfer complexation
- Use of plant polyphenols as full-fledged medicines
